IL-27 and TGFb mediated expansion of Th1 and adaptive regulatory T cells expressing IL-10 correlates with bacterial burden and disease severity in pulmonary tuberculosis
نویسندگان
چکیده
IL-27 and TGFb mediated expansion of Th1 and adaptive regulatory T cells expressing IL-10 correlates with bacterial burden and disease severity in pulmonary tuberculosis Nathella P. Kumar, Kadar Moideen, Vaithilingam V. Banurekha, Dina Nair, Rathinam Sridhar, Thomas B. Nutman, & Subash Babu National Institutes of Health—International Center for Excellence in Research, Chennai, India National Institute for Research in Tuberculosis, Chennai, India Government Stanley Medical Hospital, Chennai, India Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
منابع مشابه
IL-27 and TGFβ mediated expansion of Th1 and adaptive regulatory T cells expressing IL-10 correlates with bacterial burden and disease severity in pulmonary tuberculosis
CD4(+) T cell expression of IL-10 is an important mechanism controlling immunity to tuberculosis (TB). To identify the CD4(+) T cell subsets producing IL-10 in human TB, we enumerated the frequencies of IL-10 expressing CD4(+) T cell subsets following TB-antigen stimulation of cells from individuals with pulmonary (PTB) and latent TB (LTB). We first demonstrate that TB antigens induce an expans...
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